American Board of Internal Medicine (ABIM) Certification Practice Exam

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Which of the following is a common treatment for adult-onset Still disease?

High-dose NSAIDs
Antibiotics
Colchicine
Biologic agents

The correct answer is: High-dose NSAIDs

High-dose nonsteroidal anti-inflammatory drugs (NSAIDs) are indeed a common treatment for adult-onset Still disease, which is characterized by fevers, joint pain, and a salmon-colored rash. NSAIDs help manage the inflammation and pain associated with this condition, making them an essential part of the initial therapeutic approach. In adult-onset Still disease, inflammation is a key issue, and NSAIDs are typically the first line of treatment due to their anti-inflammatory properties. While biologic agents may be used in more severe or refractory cases, it is usually after NSAIDs have been tried. Antibiotics are not relevant in the treatment of Still disease as it is not caused by an infection, and colchicine is more commonly associated with gout and certain inflammatory conditions rather than adult-onset Still disease. Thus, high-dose NSAIDs provide a practical and effective first step in the management of this systemic inflammatory condition.