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The focus of treatment for iliotibial band syndrome primarily revolves around activity modification and nonsteroidal anti-inflammatory drugs (NSAIDs). This condition often arises from repetitive friction or overuse, particularly in runners and cyclists. The primary approach is to reduce inflammation and alleviate pain through rest and the application of NSAIDs, while simultaneously modifying activities that exacerbate the symptoms.

In contrast, the other conditions listed often require different treatment strategies. Pes anserine bursitis, while it may involve similar management strategies, can also benefit significantly from targeted physical therapy to address underlying factors. Medial collateral ligament tears typically require a more comprehensive approach that may include physical therapy, bracing, or even surgical intervention in severe cases. Ankle sprains, depending on their severity, may demand immobilization or rehabilitation strategies beyond just NSAIDs and activity modification.

In summary, the management of iliotibial band syndrome emphasizes conservative measures tailored to reduce repetitive strain, making activity modification and NSAIDs the cornerstone of its treatment.