American Board of Internal Medicine (ABIM) Certification Practice Exam

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Which GLP-1 analogue is specifically noted for being associated with delayed gallbladder emptying?

Liraglutide
Semaglutide
Exenatide
Dulaglutide

The correct answer is: Exenatide

The GLP-1 analogue known for being specifically associated with delayed gallbladder emptying is exenatide. This effect can be attributed to exenatide's mechanism of action, which involves slowing gastric motility and gastrointestinal transit. These actions can lead to alterations in gallbladder function, impacting the timing of gallbladder emptying. While liraglutide, semaglutide, and dulaglutide are also GLP-1 receptor agonists with similar mechanisms, they have not been specifically highlighted for delayed gallbladder emptying in the same way as exenatide. Understanding the unique physiological effects of these medications on digestion and gallbladder function can help healthcare providers manage potential side effects in patients who are prescribed these therapies.