American Board of Internal Medicine (ABIM) Certification Practice Exam

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Which agent is often prescribed for managing fatigue in MS patients?

Armodafinil
Gabapentin
Pregabalin
Fluoxetine

The correct answer is: Armodafinil

Armodafinil is primarily used to enhance wakefulness and manage fatigue, particularly in conditions like multiple sclerosis (MS). Fatigue is a common and debilitating symptom of MS, affecting the quality of life for many patients. Armodafinil, a wakefulness-promoting agent, operates by affecting certain neurotransmitters in the brain, which can help improve energy levels and reduce the sensation of fatigue. Unlike other medications options, such as gabapentin and pregabalin, which are primarily used for neuropathic pain, or fluoxetine, an antidepressant that may help with mood-related issues in MS, armodafinil directly targets fatigue, making it a more suitable choice for this specific symptom in MS patients. This targeted approach to managing fatigue is why armodafinil is often prescribed in such contexts.