American Board of Internal Medicine (ABIM) Certification Practice Exam

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When should a revaccination dose of PPSV23 be given?

3 years after first dose
5 years after first dose
10 years after first dose
Upon reaching age 65

The correct answer is: 5 years after first dose

A revaccination dose of Pneumococcal Polysaccharide Vaccine (PPSV23) is typically recommended for certain individuals who are at increased risk of developing pneumococcal disease. The Centers for Disease Control and Prevention (CDC) guidelines suggest that for adults aged 19 through 64 years who receive a first dose of PPSV23 and are at high risk due to conditions such as chronic medical conditions or immunocompromising conditions, a revaccination should be given 5 years after the first dose. This recommendation is based on the understanding that immunity from the pneumococcal vaccine diminishes over time, and individuals at higher risk remain vulnerable to infection. Revaccination helps enhance and maintain protective immunity against invasive pneumococcal diseases. While revaccination can be considered for certain populations after age 65, the specific interval of 5 years after the first dose is the guideline for earlier administrations. Confirmation of an individual's immunization history, age, and health status is necessary to ensure appropriate vaccination decisions.