American Board of Internal Medicine (ABIM) Certification Practice Exam

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What should patients taking AEDs be regularly screened for?

Allergic reactions
Suicidal thoughts
Drug interactions
Cardiovascular issues

The correct answer is: Suicidal thoughts

Patients taking antiepileptic drugs (AEDs) should be regularly screened for suicidal thoughts. This is particularly important because studies have shown an increased risk of suicidality associated with several AEDs. The exact mechanism behind this phenomenon is not fully understood, but it is believed to involve effects on neurotransmitters and mood regulation. Monitoring for suicidal thoughts enables early identification and intervention, which is crucial since these medications are often prescribed for chronic conditions. Recognizing any changes in mental health can lead to timely adjustments in therapy, providing better overall care and helping to prevent any adverse outcomes related to suicidality. While screening for allergic reactions, drug interactions, and cardiovascular issues is important in the management of patients on AEDs, the specific focus on mental health—particularly suicidal ideation—addresses a critical aspect of the long-term management and safety of these patients.