American Board of Internal Medicine (ABIM) Certification Practice Exam

What screening method is recommended for ovarian cancer in women with BRCA1/2 mutations starting at age 30?

1. Annual MRIs

2. Semiannual pelvic examinations

3. Daily self-examinations

4. Monthly ultrasounds

The correct answer is: Semiannual pelvic examinations

The recommended screening method for ovarian cancer in women with BRCA1/2 mutations starting at age 30 involves semiannual pelvic examinations. This recommendation is based on the elevated risk these women face for developing ovarian cancer due to their genetic mutations. Regular pelvic examinations allow clinicians to monitor for any changes or abnormalities that may indicate the presence of ovarian cancer, providing an opportunity for early detection which is crucial in improving outcomes. In contrast to other options, such as annual MRIs, daily self-examinations, or monthly ultrasounds, semiannual pelvic examinations combine clinical skill and patient assessment. While imaging modalities can be utilized in higher-risk populations, they are not typically the frontline screening method recommended. Self-examinations, while empowering for patients, do not substitute for clinical evaluations and cannot reliably detect ovarian cancer. Therefore, the semiannual approach aligns with clinical guidelines focusing on the importance of regular professional evaluations for women at increased risk due to BRCA mutations.