American Board of Internal Medicine (ABIM) Certification Practice Exam

What is the purpose of dalfampridine in multiple sclerosis patients?

1. Boosting cognitive function

2. Improving lower extremity function

3. Reducing seizures

4. Enhancing visual acuity

The correct answer is: Improving lower extremity function

Dalfampridine is specifically indicated for the treatment of walking impairment in patients with multiple sclerosis (MS). It works by blocking potassium channels, which leads to increased conduction of action potentials in demyelinated axons. This helps to improve the speed and efficiency of nerve signaling, ultimately enhancing the ability of patients with MS to walk more effectively. By focusing on the improvement of lower extremity function, dalfampridine addresses one of the most common and debilitating symptoms of MS, which is difficulty walking. Patients often report a clearer improvement in their mobility and walking speed after treatment with dalfampridine, making it a crucial part of managing this particular aspect of multiple sclerosis. Other purposes listed, such as boosting cognitive function, reducing seizures, or enhancing visual acuity, do not apply to dalfampridine. Cognitive function in MS is managed with different therapeutic approaches, antiepileptic medications address seizure control, and visual disturbances may require specific treatments depending on the underlying cause but are not affected by dalfampridine.