American Board of Internal Medicine (ABIM) Certification Practice Exam

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What is the expected long-term prognosis for patients with thin glomerular basement membrane disease?

Poor with frequent kidney failure
Excellent with rare progression to chronic kidney disease
Variable based on treatment
Dependent on lifestyle changes

The correct answer is: Excellent with rare progression to chronic kidney disease

Thin glomerular basement membrane disease typically results in a favorable long-term prognosis for patients. This condition is characterized by a thinning of the glomerular basement membrane, which is often associated with benign urinary findings such as hematuria and proteinuria, but it does not generally lead to significant progression to chronic kidney disease or kidney failure. Most patients maintain stable renal function over time, with a low incidence of progressing to end-stage renal disease. This reflects the benign nature of the disease, which contrasts with other glomerular pathologies that may result in more serious renal complications. Therefore, it is accurate to state that for patients with thin glomerular basement membrane disease, the long-term outlook is excellent, with infrequent advancement to chronic kidney disease.