American Board of Internal Medicine (ABIM) Certification Practice Exam

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What is one indication for PPSV23 vaccination?

Cirrhosis
Diabetes insipidus
Peptic ulcer disease
Autoimmune disorders

The correct answer is: Cirrhosis

Pneumococcal polysaccharide vaccine (PPSV23) is recommended for various high-risk groups to prevent pneumonia and other pneumococcal diseases. One significant indication for its use is in patients with cirrhosis. Individuals with liver disease, particularly those with cirrhosis, are at an increased risk for infections, including invasive pneumococcal disease. The immune system may be compromised in these patients, making vaccination crucial for prevention. In contrast, while conditions such as diabetes insipidus, peptic ulcer disease, and certain autoimmune disorders can also affect health, they do not carry the same level of increased risk for pneumococcal infections as cirrhosis does. Therefore, emphasizing vaccination in individuals with cirrhosis plays a vital role in reducing complications associated with pneumonia and supporting overall health in this high-risk population.