American Board of Internal Medicine (ABIM) Certification Practice Exam

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Tofacitinib is associated with a risk of causing which abnormal condition?

Elevated blood pressure
Liver dysfunction
Abnormal lipid profile
Bone marrow suppression

The correct answer is: Abnormal lipid profile

Tofacitinib, a Janus kinase (JAK) inhibitor used primarily for treating conditions like rheumatoid arthritis, is known to affect the lipid metabolism in patients. Specifically, it can lead to an abnormal lipid profile characterized by increased levels of total and low-density lipoprotein (LDL) cholesterol. This effect is particularly important as it signifies a potential cardiovascular risk that needs to be monitored in patients undergoing treatment with Tofacitinib. The other conditions listed may have associations with different medications or conditions but are not specifically linked to Tofacitinib in the same way. It is essential for healthcare providers to be aware of this potential for lipid abnormalities when prescribing Tofacitinib, allowing for appropriate monitoring and management of the patient's cardiovascular health.